MCUT Research

Carbohydrate Polymers/ 2026, vol. 382, p.125245 (IF: 12.5, Ranking: 1/57 (2%), Chemistry, Organic)

Chitosan/Fe₃O₄/graphene nanoplatelets composites-modified glassy carbon electrode for highly sensitive electrochemical detection of dopamine, uric acid, and ascorbic acid

Andri Hardiansyah (BRIN), Rifqi Fajar Maulana (BRIN-MCUT TEEP student), Yu-Wei Cheng (MCUT), Ting-Yu Liu (MCUT)

This study presents a chitosan/Fe₃O₄/graphene nanoplatelet (CS@Fe₃O₄/GNP) nanocomposite-modified glassy carbon electrode for highly sensitive electrochemical detection of dopamine (DA), uric acid (UA), and ascorbic acid (AA). The synergistic integration of conductive GNP, electrocatalytic Fe₃O₄, and biocompatible chitosan enhances electron transfer and analyte selectivity. The optimized sensor (0.25% CS) achieved low detection limits of 28.37 nM (DA), 566.27 nM (UA), and 26.54 μM (AA), with excellent linearity and reproducibility. Distinct peak separation enables simultaneous detection, particularly for DA and UA. Practical applicability was confirmed in human serum with high recovery rates, demonstrating strong potential for biomedical sensing applications. (https://doi.org/10.1016/j.carbpol.2026.125245)

This sensor can be applied in clinical diagnostics for monitoring dopamine, uric acid, and ascorbic acid, enabling early detection of neurological and metabolic disorders. It is suitable for point-of-care testing, portable biosensors, and real-time health monitoring devices, demonstrating strong potential for biomedical and healthcare applications.

This work highlights global collaboration by involving TEEP students (Mr. Rifqi Fajar Maulana form BRIN) at Ming Chi University of Technology (MCUT), fostering international research exchange and talent development. Nationally, it advances Taiwan’s biomedical sensing capabilities and innovation, while globally contributing to affordable, sensitive diagnostic technologies for improved healthcare access and disease monitoring.